1H-pyrazole-4,5-dicarbonyl dichloride -Drug Synthesis Database

【结构式】

【分子编号】63580

【品名】1H-pyrazole-4,5-dicarbonyl dichloride

【CA登记号】

【分子式】C₅H₂Cl₂N₂O₂

【分子量】192.98856

【元素组成】C 31.12% H 1.04% Cl 36.74% N 14.52% O 16.58%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

In an alternative method, chlorination of pyrazole-3,4-dicarboxylic acid (I) with SOCl2 produces acid chloride (II), which is further converted into diamide (III) upon treatment with ammonia. Subsequent Hofmann rearrangement of amide (III) in the presence of sodium hypochlorite leads to the target pyrazolopyrimidine compound (3, 4).

参考文献中间体

合成目标

【1】 Hitchings, G.H.; Falco, E.A. (GlaxoSmithKline Inc.); Treatment of hyperuricemia in humans. GB 0798646; US 3624205 .
【2】 Hitchings, G.H.; Faco, E.A. (GlaxoSmithKline Inc.); Pyrazolo-(3,4-d) pyrimidines. US 3474098 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	63579	1H-pyrazole-4,5-dicarboxylic acid	C₅H₄N₂O₄	详情	详情
(II)	63580	1H-pyrazole-4,5-dicarbonyl dichloride	C₅H₂Cl₂N₂O₂	详情	详情
(III)	63581	1H-pyrazole-4,5-dicarboxamide	C₅H₆N₄O₂	详情	详情

Extended Information