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【结 构 式】 
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【分子编号】63579 【品名】1H-pyrazole-4,5-dicarboxylic acid 【CA登记号】 |
【 分 子 式 】C5H4N2O4 【 分 子 量 】156.09784 【元素组成】C 38.47% H 2.58% N 17.95% O 41% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)In an alternative method, chlorination of pyrazole-3,4-dicarboxylic acid (I) with SOCl2 produces acid chloride (II), which is further converted into diamide (III) upon treatment with ammonia. Subsequent Hofmann rearrangement of amide (III) in the presence of sodium hypochlorite leads to the target pyrazolopyrimidine compound (3, 4).
| 【1】 Hitchings, G.H.; Falco, E.A. (GlaxoSmithKline Inc.); Treatment of hyperuricemia in humans. GB 0798646; US 3624205 . |
| 【2】 Hitchings, G.H.; Faco, E.A. (GlaxoSmithKline Inc.); Pyrazolo-(3,4-d) pyrimidines. US 3474098 . |
Extended Information