|
【结 构 式】 
|
【分子编号】63419 【品名】 【CA登记号】 |
【 分 子 式 】C14H12Cl6N2O2Pt 【 分 子 量 】648.05776 【元素组成】C 25.95% H 1.87% Cl 32.82% N 4.32% O 4.94% Pt 30.1% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The dichloroplatinum(II) complex (II) is synthesized by reacting K2PtCl4 with meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine (I) in tert-BuOH / H2O or DMF / H2O at pH 5-6 and temperature below 40 C. The corresponding sulfatoplatinum(II) complex D-19384 is obtained by addition of Ag2SO4 to a suspension of the dichloro complex (II) in H20 at 40 C.
| 【1】 Schonenberger, H.; Von Argerer, E.; Karl, J.; Jennerwein, M.; Engel, J. (Asta Medica AG); Tumor inhibitor (1,2-diphenyl-ethylendiamine)-plat. DE 3604866; EP 0193055; ES 8707920; JP 1986194095; US 4730068 . |
| 【2】 Lux, F.; Hilgard, P.; Respondek, J.M.; Karl, J.; Engel, J.; Schonenberger, H.; Schumacher, W.; D-19384. Drugs Fut 1988, 13, 3, 215. |
Extended Information