【结 构 式】 |
【分子编号】63390 【品名】phenylmethyl 3-cyclohexyl-2-[(4-morpholinylcarbonyl)amino]propanoate 【CA登记号】 |
【 分 子 式 】C21H30N2O4 【 分 子 量 】374.48028 【元素组成】C 67.35% H 8.07% N 7.48% O 17.09% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)Cyclohexylalanine benzyl ester (I) is acylated by 4-morpholinecarbonyl chloride (II) to furnish the urea derivative (III). The benzyl ester group of (III) is then removed by transfer hydrogenolysis, yielding N-(4-morpholinecarbonyl)-L-cyclohexylalanine (IV).
【1】 Frye, L.L.; Cywin, C.L.; Morwick, T.; Spero, D.M.; Thomson, D.; Ward, Y. (Boehringer Ingelheim Pharmaceuticals Inc.); Cpds. useful as reversible inhibitors of cathepsin S. JP 2002538151; US 6395897; WO 0051998 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 63389 | phenylmethyl 2-amino-3-cyclohexylpropanoate | C16H23NO2 | 详情 | 详情 | |
(II) | 15847 | 4-morpholinecarbonyl chloride; Morpholine-4-carbonyl chloride | 15159-40-7 | C5H8ClNO2 | 详情 | 详情 |
(III) | 63390 | phenylmethyl 3-cyclohexyl-2-[(4-morpholinylcarbonyl)amino]propanoate | C21H30N2O4 | 详情 | 详情 | |
(IV) | 63391 | 3-cyclohexyl-N-(4-morpholinylcarbonyl)alanine | C14H24N2O4 | 详情 | 详情 |
Extended Information