• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】62832

【品名】N-[3-(3,5-dichloro-4-tricyclo[3.3.1.1~3,7~]dec-2-ylphenyl)-2-propynyl]-N-ethylcyclohexanamine; N-cyclohexyl-N-[3-(3,5-dichloro-4-tricyclo[3.3.1.1~3,7~]dec-2-ylphenyl)-2-propynyl]-N-ethylamine

【CA登记号】

【 分 子 式 】C27H35Cl2N

【 分 子 量 】444.48704

【元素组成】C 72.96% H 7.94% Cl 15.95% N 3.15%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IX)

Alkylation of cyclohexyl ethylamine (VI) with propargyl bromide (VII) gives the tertiary amine (VIII). Then, palladium-catalyzed coupling between the propargylic amine (VIII) and aryl triflate (V) furnishes the disubstituted acetylene derivative (IX). Finally, semihydrogenation of the triple bond of (IX) in the presence of cyclohexene and Lindlar catalyst gives rise to the target cis-olefin.

1 Paul, R.; Boigegrain, R.; Nisato, D.; Casellas, P.; Herbert, J.M.; Bourrie, B.; Bourrie, M.; Lair, P.; Vernieres, J.C. (Sanofi-Synthélabo); Benzene derivs., preparation method and pharmaceutical compsns. containing same. EP 1192122; FR 2794742; JP 2003502306; US 6482986; WO 0076953 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(V) 62830 3,5-dichloro-4-tricyclo[3.3.1.1~3,7~]dec-2-ylphenyl trifluoromethanesulfonate C17H17Cl2F3O3S 详情 详情
(VI) 59245 N-Ethylcyclohexanamine; N-Ethylcyclohexylamine; Vulkacit HX 5459-93-8 C8H17N 详情 详情
(VII) 11176 3-Bromopropyne; 3-Bromo-1-propyne 106-96-7 C3H3Br 详情 详情
(VIII) 62831 N-ethyl-N-(2-propynyl)cyclohexanamine; N-cyclohexyl-N-ethyl-N-(2-propynyl)amine C11H19N 详情 详情
(IX) 62832 N-[3-(3,5-dichloro-4-tricyclo[3.3.1.1~3,7~]dec-2-ylphenyl)-2-propynyl]-N-ethylcyclohexanamine; N-cyclohexyl-N-[3-(3,5-dichloro-4-tricyclo[3.3.1.1~3,7~]dec-2-ylphenyl)-2-propynyl]-N-ethylamine C27H35Cl2N 详情 详情
Extended Information