合成路线1

4,6-Dimethylindole (I) is reduced to the corresponding indoline (II) with NaBH3CN in AcOH. After acylation with Ac2O, the resultant N-acetylindoline (III) is brominated by means of Br2 in AcOH to give the 5-bromoindoline derivative (IV). Nitration of (IV) with fuming HNO3 in H2SO4/AcOH provides the 7-nitro indoline (V). Then, simultaneous debromination and nitro group reduction in (V) is accomplished by hydrogenation in the presence of Pd/C to furnish aniline (VI). Further acylation of (VI) with pivaloyl chloride leads to diamide (VII). The N-acetyl group of (VII) is selectively removed under alkaline hydrolysis conditions to yield indoline (VIII). Finally, alkylation of (VIII) with 1-bromodecane and K2CO3 furnishes the title compound.