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【结 构 式】 
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【分子编号】62713 【品名】diethyl 2-[4-(3-methyl-2-thienyl)phenyl]malonate 【CA登记号】 |
【 分 子 式 】C18H20O4S 【 分 子 量 】332.4204 【元素组成】C 65.04% H 6.06% O 19.25% S 9.65% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XLIII)Methylation of arylacetic ester (XLII) was accomplished via Claisen condensation with diethyl carbonate and alkylation of the resultant arylmalonate (XLIII) with iodomethane and NaOMe. The methylated compound (XLIV) was further subjected to hydrolysis and decarboxylation to give (IX)
| 【2】 Arai, H.; Tanaka, K.; Watanabe, I.; Kodama, T.; Hirano, H.; Abe, N.; Nakabayashi, M. (Toyama Chemical Co., Ltd.); Novel 2-[4-(3-methyl-2-thienyl)phenyl]propionic acid and pharmaceutically acceptable salt thereof and method for treating symptoms of inflammation and pain. US 4230719 . |
| 【1】 Kodama, T.; Nakabayashi, M.; Watanabe, I.; Hirano, Y.; Abe, N.; Tanaka, K.; Arai, H. (Toyama Chemical Co., Ltd.); 2-[4-(3-Methyl-2-thienyl)phenyl]propionic acid derivs. and its non-toxic salts. DE 2850485; JP 1981049376 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 62687 | 2-[4-(3-methyl-2-thienyl)phenyl]propanoic acid | C14H14O2S | 详情 | 详情 | |
| (XLII) | 62712 | ethyl 2-[4-(3-methyl-2-thienyl)phenyl]acetate | C15H16O2S | 详情 | 详情 | |
| (XLIII) | 62713 | diethyl 2-[4-(3-methyl-2-thienyl)phenyl]malonate | C18H20O4S | 详情 | 详情 | |
| (XLIV) | 62714 | diethyl 2-methyl-2-[4-(3-methyl-2-thienyl)phenyl]malonate | C19H22O4S | 详情 | 详情 |
Extended Information