• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】62033

【品名】3-[(1S)-4,4-dimethyl-3-oxo-1-(6-oxo-2-{[(1R)-1-phenylethyl]amino}-1-cyclohexen-1-yl)pentyl]benzonitrile

【CA登记号】

【 分 子 式 】C28H32N2O2

【 分 子 量 】428.57436

【元素组成】C 78.47% H 7.53% N 6.54% O 7.47%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VII)

The condensation of 3-cyanobenzaldehyde (I) with trifluoroacetone (II) in piperidine gives 3-(4,4,4-trifluoro-3-oxo-2-butenyl)benzonitrile (III). The condensation of cyclohexane-1,3-dione (IV) with 1(R)-phenylethylamine (V) in refluxing toluene or THF yields the secondary enamine (VI), which is condensed with benzonitrile (III) by means of Tms-Cl in hot acetonitrile to afford the chiral adduct (VII). The cyclization of (VII) by means of NH3 in hot acetonitrile provides the chiral octahydroquinolone (VIII), which is finally dehydrated by means of TFA, MsOH, TsOH or HCl in refluxing acetonitrile to give the target hexahydroquinolone.

1 Patel, I.; Hopes, P. (AstraZeneca AB); Process for synthesis of alpha,beta-unsaturated ketones. WO 0210103 .
2 Patel, I.; Ashworth, I.; Levin, D. (AstraZeneca AB); Process for asymmetric synthesis of substd. 1,4-dihydropyridines. WO 0210134 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 13245 3-Formylbenzonitrile; 3-Cyanobenzaldehyde 24964-64-5 C8H5NO 详情 详情
(II) 35450 3,3-dibromo-1,1,1-trifluoroacetone 431-67-4 C3HBr2F3O 详情 详情
(III) 62031 3-[(E)-4,4,4-trifluoro-3-oxo-1-butenyl]benzonitrile C11H6F3NO 详情 详情
(IV) 11244 1,3-Cyclohexanedione 504-02-9 C6H8O2 详情 详情
(V) 10039 (1R)-1-Phenylethylamine; (1R)-1-Phenyl-1-ethanamine.; L-alpha-Phenylethylamine 3886-69-9 C8H11N 详情 详情
(VI) 62032 3-{[(1R)-1-phenylethyl]amino}-2-cyclohexen-1-one C14H17NO 详情 详情
(VII) 62033 3-[(1S)-4,4-dimethyl-3-oxo-1-(6-oxo-2-{[(1R)-1-phenylethyl]amino}-1-cyclohexen-1-yl)pentyl]benzonitrile C28H32N2O2 详情 详情
(VIII) 62034 3-[(4S)-2-hydroxy-5-oxo-2-(trifluoromethyl)-1,2,3,4,5,6,7,8-octahydro-4-quinolinyl]benzonitrile C17H15F3N2O2 详情 详情
Extended Information