8-cyclopentyl-6-(methylsulfonyl)-3-propyl-3,7-dihydro-2H-purin-2-one -Drug Synthesis Database

【结构式】

【分子编号】61417

【品名】8-cyclopentyl-6-(methylsulfonyl)-3-propyl-3,7-dihydro-2H-purin-2-one

【CA登记号】

【分子式】C₁₄H₂₀N₄O₃S

【分子量】324.40396

【元素组成】C 51.83% H 6.21% N 17.27% O 14.8% S 9.88%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

In a related method, the purine thioether (I) is oxidized to sulfone (II) by means of oxone under phase-transfer conditions. Coupling of sulfone (II) with the pyridyl amino alcohol (III) yields adduct (IV), which is finally cyclized to the target tricyclic compound upon treatment with thionyl chloride.

参考文献中间体

合成目标

【1】 Nomoto, Y.; Nakanishi, S.; Ohta, Y.; Ogawa, A.; Suzuki, C.; Ueno, K.; Yano, H.; Kusaka, H.; Takasaki, K. (Kyowa Hakko Kogyo Co., Ltd.); Fused purine derivs.. EP 1251130; WO 0147931 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	61415	8-cyclopentyl-6-(methylsulfanyl)-3-propyl-3,7-dihydro-2H-purin-2-one	C₁₄H₂₀N₄OS	详情	详情
(II)	61417	8-cyclopentyl-6-(methylsulfonyl)-3-propyl-3,7-dihydro-2H-purin-2-one	C₁₄H₂₀N₄O₃S	详情	详情
(III)	61414	(2R)-2-amino-3-(4-pyridinyl)-1-propanol	C₈H₁₂N₂O	详情	详情
(IV)	61416	8-cyclopentyl-6-{[(1R)-2-hydroxy-1-(4-pyridinylmethyl)ethyl]amino}-3-propyl-3,7-dihydro-2H-purin-2-one	C₂₁H₂₈N₆O₂	详情	详情

Extended Information