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【结 构 式】 
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【分子编号】60191 【品名】1,1-dimethylethyl 1,3,4,9-tetrahydro-2H-beta-carboline-2-carboxylate 【CA登记号】 |
【 分 子 式 】C16H20N2O2 【 分 子 量 】272.34708 【元素组成】C 70.56% H 7.4% N 10.29% O 11.75% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)Intermediate (III) is prepared by the following route. Acylation of 2-Boc-tetrahydropyridoindole (I) with dimethylcarbamoyl chloride provides the 9-carbamoyl derivative (II). Subsequent Boc group cleavage under acidic conditions furnishes amine (III).
| 【1】 Koyama, M.; Okuno, M.; Hiranuma, T.; Ando, T.; Fuji, K.; Ushiroda, O.; Kikuchi, C.; Shiiyama, M.; Satoh, E. (Meiji Seika Kaisha, Ltd.); Tetrahydrobenzindole derivs.. EP 1057814; JP 1999189585; US 6498251; WO 9933804 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 60191 | 1,1-dimethylethyl 1,3,4,9-tetrahydro-2H-beta-carboline-2-carboxylate | C16H20N2O2 | 详情 | 详情 | |
| (II) | 60192 | 1,1-dimethylethyl 9-[(dimethylamino)carbonyl]-1,3,4,9-tetrahydro-2H-beta-carboline-2-carboxylate | C19H25N3O3 | 详情 | 详情 | |
| (III) | 60193 | N,N-dimethyl-1,2,3,4-tetrahydro-9H-beta-carboline-9-carboxamide | C14H17N3O | 详情 | 详情 |
Extended Information