2-chloro-1-methyl-1H-benzimidazole -Drug Synthesis Database

【结构式】

【分子编号】62796

【品名】2-chloro-1-methyl-1H-benzimidazole

【CA登记号】

【分子式】C₈H₇ClN₂

【分子量】166.60976

【元素组成】C 57.67% H 4.23% Cl 21.28% N 16.81%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

Alkylation of 2-chlorobenzimidazole (VI) with iodomethane and NaOH leads to 2-chloro-1-methylbenzimidazole (VII). The 2-chloro group of (VII) is then displaced with hydrazine hydrate to afford hydrazine (VIII). Finally, condensation between ketone (V) and hydrazine (VIII) gives rise to the target hydrazone.

参考文献中间体

合成目标

【1】 Easmon, J.; Fürtinger, S.; Lackner, G. ; Magreiter, E.; Hofmann, J.; Heinisch, G.; Puerstinger, G.; Hydrazones derived from monosubstitued 2-acetylpyridines and 2-hydrazino-1-methylbenzimidazole: Synthesis and biological studies. Eur J Cancer 2002, 38, Suppl. 7.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(V)	62795	1-(5-methyl-2-pyridinyl)-1-ethanone		C₈H₉NO	详情	详情
(VI)	26761	2-chloroimidazo[1,2-a]pyridine; 2-chlorobenzimidazole; 2-Amino-4'-chlorodiphenylether; 2-Aminodiphenylether; 2-chloro-1H-benzimidazole	4857-06-1	C₇H₅ClN₂	详情	详情
(VII)	62796	2-chloro-1-methyl-1H-benzimidazole		C₈H₇ClN₂	详情	详情
(VIII)	62797	2-hydrazino-1-methyl-1H-benzimidazole		C₈H₁₀N₄	详情	详情

Extended Information