|
【结 构 式】 
|
【分子编号】59256 【品名】 【CA登记号】 |
【 分 子 式 】C23H24FNO2 【 分 子 量 】365.4475032 【元素组成】C 75.59% H 6.62% F 5.2% N 3.83% O 8.76% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Formation of the diastereoisomeric salts with (R)-alpha-methylbenzylamine (II), followed by crystallization from methanol/toluene, provided the desired (R)-phenylpropionic acid salt (III) in good enantiomeric purity, which was further enriched in the desired enantiomer by recrystallization from the same solvent. The chiral carboxylic acid was then liberated from the recrystallized methylbenzylamine salt (III) by acidification with HCl in a water/heptane two-phase system.
| 【1】 Coe, P.F.; Hardy, R.; Hirst, A.; O'Donnell, H.O. (The Boots Company plc); Process for preparing substantially pure enantiomers of phenylpropionic acids. WO 9412460 . |
Extended Information