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【结 构 式】 
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【分子编号】59139 【品名】(4R)-3-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic 1,1-dimethylpropanoic anhydride 【CA登记号】 |
【 分 子 式 】C29H48O5 【 分 子 量 】476.69712 【元素组成】C 73.07% H 10.15% O 16.78% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VI)In a related method, ursodeoxycholic acid (I) was activated as either the mixed anhydrides (VI) or (VII) with pivaloyl chloride or benzoyl chloride, respectively. Subsequent coupling with taurine (III) produced the title conjugated bile acid.
| 【1】 Rossetti, V.; Arosio, R. (Sanofi-Synthelabo); Process for the preparation of taurocholic acids. EP 0629634 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 48093 | (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid | 128-13-2 | C24H40O4 | 详情 | 详情 |
| (III) | 34828 | 2-amino-1-ethanesulfonic acid | 107-35-7 | C2H7NO3S | 详情 | 详情 |
| (VI) | 59139 | (4R)-3-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic 1,1-dimethylpropanoic anhydride | C29H48O5 | 详情 | 详情 | |
| (VII) | 59140 | 1-benzenecarboxylic (4R)-3-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic anhydride | C31H44O5 | 详情 | 详情 |
Extended Information