5-(4-chlorophenyl)-1-(2,4-dichloro-3-iodophenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide -Drug Synthesis Database

【结构式】

【分子编号】58226

【品名】5-(4-chlorophenyl)-1-(2,4-dichloro-3-iodophenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide

【CA登记号】

【分子式】C₂₂H₂₀Cl₃IN₄O

【分子量】589.68973

【元素组成】C 44.81% H 3.42% Cl 18.04% I 21.52% N 9.5% O 2.71%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of Rimonabant (I) with BuLi and 1-chloro-2-iodoethane gives a mixture of the iodo derivatives (II) and (III), which are separated by chromatography. The desired isomer (II) is then hydrogenated with tritium over Pd/C in ethanol.

参考文献中间体

合成目标

【1】 Seltzman, H.H.; et al.; Tritiation of SR141716 by metallation-iodination-reduction: Tritium-proton nOe study. J Label Compd Radiopharm 2002, 45, 1, 59.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	58224	5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide	C₂₂H₂₁Cl₃N₄O	详情	详情
(II)	58225	5-(4-chlorophenyl)-1-(2,4-dichloro-6-iodophenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide	C₂₂H₂₀Cl₃IN₄O	详情	详情
(III)	58226	5-(4-chlorophenyl)-1-(2,4-dichloro-3-iodophenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide	C₂₂H₂₀Cl₃IN₄O	详情	详情

Extended Information