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【结 构 式】 
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【分子编号】54800 【品名】[(1-benzothiophen-2-ylsulfonyl)amino]methylphosphonic acid 【CA登记号】 |
【 分 子 式 】C9H10NO5PS2 【 分 子 量 】307.287902 【元素组成】C 35.18% H 3.28% N 4.56% O 26.03% P 10.08% S 20.87% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Addition of formaldehyde to benzothiophene-2-sulfonamide (I), followed by condensation with trimethyl phosphite, furnished the dimethyl (sulfonamidomethyl)phosphonate (II). The phosphonate ester function of (II) was then hydrolyzed by means of bromotrimethylsilane, producing phosphonic acid (III). This was finally coupled to 2-fluoro-4-nitrophenol (IV) using trichloroacetonitrile in hot pyridine to afford the title mono-phosphonate ester.
| 【1】 Stutz, A. (Novartis AG); Propenylamines, pharmaceutical compositions containing them and their use as pharmaceuticals. EP 0024587; JP 56032440; JP 63313753; Us 4755534 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 54798 | 1-benzothiophene-2-sulfonamide | C8H7NO2S2 | 详情 | 详情 | |
| (II) | 54799 | dimethyl [(1-benzothiophen-2-ylsulfonyl)amino]methylphosphonate | C11H14NO5PS2 | 详情 | 详情 | |
| (III) | 54800 | [(1-benzothiophen-2-ylsulfonyl)amino]methylphosphonic acid | C9H10NO5PS2 | 详情 | 详情 | |
| (IV) | 54801 | 2-Fluoro-4-nitrophenol; 4-Nitro-2-fluorophenol | 403-19-0 | C6H4FNO3 | 详情 | 详情 |
Extended Information