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【结 构 式】 
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【分子编号】53950 【品名】2,9-oxonanedione 【CA登记号】 |
【 分 子 式 】C8H12O3 【 分 子 量 】156.18148 【元素组成】C 61.52% H 7.74% O 30.73% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIV)6. The reaction of acid (XII) with refluxing acetic anhydride gives the cyclic anhydride (XIV), which is treated with aniline (II) in THF to yield the monoamide (VII). The reaction of (VII) with ethyl chloroformate and TEA in THF affords the mixed anhydride (XV), which is finally treated with hydroxylamine in methanol to afford the target hydroxamic acid with overall yields of around 58%.
| 【1】 Mai, A.; et al.; A new facile and expeditious synthesis of N-hydroxy-N'-phenyloctanediamide, a potent inducer of terminal cytodifferentiation. Org Prep Proced Int 2001, 33, 4, 391. |
Extended Information