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【结 构 式】 
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【分子编号】53139 【品名】 【CA登记号】n/a |
【 分 子 式 】C16H29N5O8 【 分 子 量 】419.43516 【元素组成】C 45.82% H 6.97% N 16.7% O 30.52% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Boc-Nitroarginine (I) was activated as the mixed anhydride (II), which was further converted to the Weinreb amide (III) upon treatment with N,O-dimethylhydroxylamine. Reduction of (III) with LiAlH4 furnished N-Boc-nitroargininal (IV). This was reductively condensed with the mono-Boc-protected ethylenediamine (V) in the presence of sodium triacetoxyborohydride, yielding amine (VI). The Boc protecting groups of (VI) were finally removed by treatment with trifluoroacetic acid to provide the title compound.
| 【1】 Hah, J.-M.; et al.; Reduced amide bond peptidomimetics. (4S)-N-(4-Amino-5-(aminoalkyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. J Med Chem 2001, 44, 16, 2667. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 32085 | N(G)-nitro-N2-(tert-butoxy-carbonyl)-L-arginine; Nalpha-(tert-butoxycarbonyl)-Nomega-nitro-L-arginine | C11H21N5O6 | 详情 | 详情 | |
| (II) | 53139 | n/a | C16H29N5O8 | 详情 | 详情 | |
| (III) | 53140 | n/a | C13H26N6O6 | 详情 | 详情 | |
| (IV) | 53141 | n/a | C11H21N5O5 | 详情 | 详情 | |
| (V) | 13241 | N-Boc-ethylenediamine;tert-butyl (2-aminoethyl)carbamate；tert-butyl 2-aminoethylcarbamate; tert-Butyl n-(2-aminoethyl)carbamate | 57260-73-8 | C7H16N2O2 | 详情 | 详情 |
| (VI) | 53142 | n/a | C18H37N7O6 | 详情 | 详情 |
Extended Information