ethyl 3-bromo-4,4-dimethoxy-1-piperidinecarboxylate -Drug Synthesis Database

【结构式】

【分子编号】53113

【品名】ethyl 3-bromo-4,4-dimethoxy-1-piperidinecarboxylate

【CA登记号】n/a

【分子式】C₁₀H₁₈BrNO₄

【分子量】296.16126

【元素组成】C 40.56% H 6.13% Br 26.98% N 4.73% O 21.61%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The 3-bromo-4-oxopiperidine-1-carboxylic acid ethyl ester (III), an intermediate in the synthesis of cisapride, has been obtained as follows: The bromination of 4-oxopiperidine-1-carboxylic acid ethyl ester (I) with Br2 in methanol followed by neutralization of the resulting HBr with NaOMe in the same solvent gives 3-bromo-4,4-dimethoxypiperidine-1-carboxylic acid ethyl ester (II), which is finally hydrolyzed with aq. 2N HBr or HCl to afford the target intermediate 3-bromo-4-oxopiperidine-1-carboxylic acid ethyl ester (III).

参考文献中间体

合成目标

【1】 Serra Masia, J.; Lombardero Fernandez, J.; Montserrat, Vidal, C. (Laboratorios Salvat SA); Ethyl 3-bromo-4-oxo-1-piperidinecarboxylate, process for obtaining it and novel intermediates for its preparation. ES 2053394 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	13486	Ethyl 4-oxo-1-piperidinecarboxylate; N-Carbethoxy-4-piperidone	29976-53-2	C₈H₁₃NO₃	详情	详情
(II)	53113	ethyl 3-bromo-4,4-dimethoxy-1-piperidinecarboxylate	n/a	C₁₀H₁₈BrNO₄	详情	详情
(III)	53112	ethyl 3-bromo-4-oxo-1-piperidinecarboxylate	95629-02-0	C₈H₁₂BrNO₃	详情	详情

Extended Information