2,3-dimethyl-3,4-dihydro-2H-pyrrol-5-yl methyl sulfide; 2,3-dimethyl-5-(methylsulfanyl)-3,4-dihydro-2H-pyrrole -Drug Synthesis Database

【结构式】

【分子编号】51177

【品名】2,3-dimethyl-3,4-dihydro-2H-pyrrol-5-yl methyl sulfide; 2,3-dimethyl-5-(methylsulfanyl)-3,4-dihydro-2H-pyrrole

【CA登记号】

【分子式】C₇H₁₃NS

【分子量】143.25296

【元素组成】C 58.69% H 9.15% N 9.78% S 22.38%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

In a more convenient method, pyrrolidinone (I) was converted to the thiolactam (IV) upon treatment with Lawesson's reagent. Alkylation of (IV) with iodomethane furnished the corresponding (S)-methyl derivative (V). This was finally condensed with dicyclopropylmethylamine (III), yielding the title compound.

参考文献中间体

合成目标

【1】 Feldman, J.; Bousquet, P.; Pfeiffer, B.; Bruban, V.; Scalbert, E.; Renard, P.; Pompermayer, K.; Schann, S.; Ehrhardt, J.-D.; Synthesis and biological evaluation of pyrrolinic isosteres of rilmenidine. Discovery of cis-I-trans-dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-amine (LNP 509), an I1 imidazoline receptor selective ligand with hypotensive activity. J Med Chem 2001, 44, 10, 1588.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	51174	4,5-dimethyl-2-pyrrolidinone	C₆H₁₁NO	详情	详情
(III)	24691	dicyclopropylmethanamine	C₇H₁₃N	详情	详情
(IV)	51176	4,5-dimethyl-2-pyrrolidinethione	C₆H₁₁NS	详情	详情
(V)	51177	2,3-dimethyl-3,4-dihydro-2H-pyrrol-5-yl methyl sulfide; 2,3-dimethyl-5-(methylsulfanyl)-3,4-dihydro-2H-pyrrole	C₇H₁₃NS	详情	详情

Extended Information