【结 构 式】 |
【分子编号】49827 【品名】5-(4-benzyl-1-piperazinyl)-2-isopropyl-2-phenylpentanenitrile 【CA登记号】 |
【 分 子 式 】C25H33N3 【 分 子 量 】375.55724 【元素组成】C 79.95% H 8.86% N 11.19% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XI)In a further procedure, 1-benzylpiperazine (VI) was alkylated with mesylate (V) to yield adduct (XI). Catalytic hydrogenolysis of the benzyl group of (XI) afforded piperazine (XII), which was finally alkylated with 2-(4-fluorophenoxy)ethyl bromide (VII) in the presence of triethylamine.
【1】 Yamamoto, N.; et al.; Discovery of a potent neuron-selective calcium channel blocker: Structure-activity relationships and neuroprotective effects of novel piperazine derivatives. 222nd ACS Natl Meet (Aug 26 2001, Chicago) 2001, Abst MEDI 51. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(V) | 49823 | 4-cyano-5-methyl-4-phenylhexyl methanesulfonate | C15H21NO3S | 详情 | 详情 | |
(VI) | 28542 | N-Benzylpiperazine; 1-Benzylpiperazine | 2759-28-6 | C11H16N2 | 详情 | 详情 |
(VII) | 20830 | 1-(2-bromoethoxy)-4-fluorobenzene; 2-bromoethyl 4-fluorophenyl ether | 332-48-9 | C8H8BrFO | 详情 | 详情 |
(XI) | 49827 | 5-(4-benzyl-1-piperazinyl)-2-isopropyl-2-phenylpentanenitrile | C25H33N3 | 详情 | 详情 | |
(XII) | 49828 | 2-isopropyl-2-phenyl-5-(1-piperazinyl)pentanenitrile | C18H27N3 | 详情 | 详情 |
Extended Information