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【结 构 式】

【分子编号】49827

【品名】5-(4-benzyl-1-piperazinyl)-2-isopropyl-2-phenylpentanenitrile

【CA登记号】

【 分 子 式 】C25H33N3

【 分 子 量 】375.55724

【元素组成】C 79.95% H 8.86% N 11.19%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XI)

In a further procedure, 1-benzylpiperazine (VI) was alkylated with mesylate (V) to yield adduct (XI). Catalytic hydrogenolysis of the benzyl group of (XI) afforded piperazine (XII), which was finally alkylated with 2-(4-fluorophenoxy)ethyl bromide (VII) in the presence of triethylamine.

1 Yamamoto, N.; et al.; Discovery of a potent neuron-selective calcium channel blocker: Structure-activity relationships and neuroprotective effects of novel piperazine derivatives. 222nd ACS Natl Meet (Aug 26 2001, Chicago) 2001, Abst MEDI 51.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(V) 49823 4-cyano-5-methyl-4-phenylhexyl methanesulfonate C15H21NO3S 详情 详情
(VI) 28542 N-Benzylpiperazine; 1-Benzylpiperazine 2759-28-6 C11H16N2 详情 详情
(VII) 20830 1-(2-bromoethoxy)-4-fluorobenzene; 2-bromoethyl 4-fluorophenyl ether 332-48-9 C8H8BrFO 详情 详情
(XI) 49827 5-(4-benzyl-1-piperazinyl)-2-isopropyl-2-phenylpentanenitrile C25H33N3 详情 详情
(XII) 49828 2-isopropyl-2-phenyl-5-(1-piperazinyl)pentanenitrile C18H27N3 详情 详情
Extended Information