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【结 构 式】 
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【分子编号】49666 【品名】(1R,3R,4Z,6Z,8E)-3-[[tert-butyl(dimethyl)silyl]oxy]-1-[(1R,2E)-1-[[tert-butyl(dimethyl)silyl]oxy]-1-methyl-3-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]-2-propenyl]-10-[[tert-butyl(diphenyl)silyl]oxy]-4,6,8-decatrienyl bis(4-methoxybenzyl) phosphate 【CA登记号】 |
【 分 子 式 】C63H89O11PSi3 【 分 子 量 】1137.623322 【元素组成】C 66.52% H 7.89% O 15.47% P 2.72% Si 7.41% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXXIII)The reaction of the OH group of (XXXII) with PCl3, Pmb-OH and H2O2 gives the phosphoric triester (XXXIII), which is finally desilylated and debenzylated by treatments first with HF in acetonitrile/water (short time) to remove the PMB esters, and then with HF and pyridine in the same solvent to remove the silyl groups.
| 【1】 Boger, D.L.; et al.; Total synthesis of fostriecin (CI-920). J Am Chem Soc 2001, 123, 18, 4161. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XXXII) | 49665 | (6R)-6-((1E,3R,4R,6R,7Z,9Z,11E)-3,6-bis[[tert-butyl(dimethyl)silyl]oxy]-13-[[tert-butyl(diphenyl)silyl]oxy]-4-hydroxy-3-methyl-1,7,9,11-tridecatetraenyl)-5,6-dihydro-2H-pyran-2-one | C47H72O6Si3 | 详情 | 详情 | |
| (XXXIII) | 49666 | (1R,3R,4Z,6Z,8E)-3-[[tert-butyl(dimethyl)silyl]oxy]-1-[(1R,2E)-1-[[tert-butyl(dimethyl)silyl]oxy]-1-methyl-3-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]-2-propenyl]-10-[[tert-butyl(diphenyl)silyl]oxy]-4,6,8-decatrienyl bis(4-methoxybenzyl) phosphate | C63H89O11PSi3 | 详情 | 详情 |
Extended Information