2-chloro-N-(1,3,3,5,5-pentamethylcyclohexyl)acetamide -Drug Synthesis Database

【结构式】

【分子编号】54964

【品名】2-chloro-N-(1,3,3,5,5-pentamethylcyclohexyl)acetamide

【CA登记号】

【分子式】C₁₃H₂₄ClNO

【分子量】245.7924

【元素组成】C 63.53% H 9.84% Cl 14.42% N 5.7% O 6.51%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

In an alternative method, the Ritter reaction of alcohol (II) with chloroacetonitrile in the presence of H2SO4 yielded the chloroacetamide (IV). This was then hydrolyzed to the desired amine by treatment with thiourea in HOAc-EtOH.

参考文献中间体

合成目标

【1】 Jirgensons, A.; et al.; A practical synthesis of tert-alkylamines via the Ritter reaction with chloroacetonitrile. Synthesis (Stuttgart) 2000, 12, 1709.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(II)	54962	1,3,3,5,5-pentamethylcyclohexanol		C₁₁H₂₂O	详情	详情
(IV)	54964	2-chloro-N-(1,3,3,5,5-pentamethylcyclohexyl)acetamide		C₁₃H₂₄ClNO	详情	详情

Extended Information