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【结 构 式】 
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【分子编号】47761 【品名】(4-oxo-4,5,6,7-tetrahydro-1-benzofuran-6-yl)methyl 4-methylbenzenesulfonate 【CA登记号】 |
【 分 子 式 】C16H16O5S 【 分 子 量 】320.36604 【元素组成】C 59.99% H 5.03% O 24.97% S 10.01% |
合成路线1
该中间体在本合成路线中的序号：(V)Acidic hydrolysis of the enol ether groups of 1,4-dihydro-3,5-dimethoxybenzyl alcohol (I) gave diketone (II). Subsequent condensation of (II) with chloroacetaldehyde in the presence of NaHCO3, followed by dehydration of the intermediate (III) upon acidic treatment, yielded the tetrahydrobenzofuranone (IV). Tosylate (V) was then prepared by reaction of alcohol (IV) with p-toluenesulfonyl chloride in cold pyridine. Finally, nucleophilic displacement of the tosylate group with benzisoxazolylpiperidine (VI) in N-methylpyrrolidone provided the title amine.
| 【1】 Casariego, I.; et al.; New CNS agent precursors. A simple and efficient route for synthesis of 6-aminomethyl-4,5,6,7-tetrahydrobenzofuran-4-ones as conformationally constrained butyrophenone analogues. Tetrahedron Lett 1997, 38, 31, 5555. |
| 【2】 Masaguer, C.F.; Casariego, I.; Raviña, E.; et al.; Conformationally constrained butyrophenones with affinity for dopamine (D1, D2, D4) and serotonin (5-HT2A, 5-HT2C) receptors: Synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics. J Med Chem 2000, 43, 24, 4678. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25566 | (3,5-dimethoxy-2,5-cyclohexadien-1-yl)methanol | C9H14O3 | 详情 | 详情 | |
| (II) | 47758 | 5-(hydroxymethyl)-1,3-cyclohexanedione | C7H10O3 | 详情 | 详情 | |
| (III) | 47759 | 2-[4-(hydroxymethyl)-2,6-dioxocyclohexyl]acetaldehyde | C9H12O4 | 详情 | 详情 | |
| (IV) | 47760 | 6-(hydroxymethyl)-6,7-dihydro-1-benzofuran-4(5H)-one | C9H10O3 | 详情 | 详情 | |
| (V) | 47761 | (4-oxo-4,5,6,7-tetrahydro-1-benzofuran-6-yl)methyl 4-methylbenzenesulfonate | C16H16O5S | 详情 | 详情 | |
| (VI) | 17910 | 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole | C12H13FN2O | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(I)The title imine derivative was prepared by condensation of the known 7-formylcamptothecin (I) with aniline (II) in the presence of ytterbium triflate and molecular sieves in CH2Cl2.
| 【1】 De Cesare, M.; Pratesi, G.; Carenini, N.; Dallavalle, S.; Penco, S.; Ferrari, A.; Merlini, L.; Zunino, F.; Perego, P.; Novel cytotoxic 7-iminomethyl and 7-aminomethyl derivatives of camptothecin. Bioorg Med Chem Lett 2001, 11, 3, 291. |
| 【2】 Carminati, P.; Penco, S.; Zunino, F.; Merlini, L. (Istituto Nazionale per lo Studio e la Cura dei Tumori; Sigma-Tau Industrie Farmaceutiche Riunite SpA); Camptothecin derivs. having antitumor activity. EP 1044977; WO 0053607 . |