【结 构 式】 |
【分子编号】47429 【品名】3-phenyl-1(2H)-isoquinolinone 【CA登记号】 |
【 分 子 式 】C15H11NO 【 分 子 量 】221.25848 【元素组成】C 81.43% H 5.01% N 6.33% O 7.23% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)3-Phenylisoquinolinone (II) was synthesized by addition of benzonitrile to the dilithium derivative of N-methyltoluamide (I). Conversion of (II) to the 1-chloroisoquinoline (III) was achieved by heating with POCl3. Then, displacement of the chlorine atom of (III) with N-methylpiperazine (IV) in refluxing DMF furnished the title compound.
【1】 Park, M.-J.; Chung, B.-H.; Cho, W.-J.; Lee, C.-O.; Yo, S.-J.; Synthesis and antitumor activity of 3-arylisoquinoline derivatives. Arch Pharmacal Res 1997, 20, 3, 264. |
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