3-buten-2-ol -Drug Synthesis Database

【结构式】

【分子编号】46055

【品名】3-buten-2-ol

【CA登记号】

【分子式】C₄H₈O

【分子量】72.10692

【元素组成】C 66.63% H 11.18% O 22.19%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

By condensation of 2-bromo-6-methoxynaphthalene (I) with 3-buten-2-ol (VI) catalyzed by Pd(OAc)2 or PdCl2, along with PPh3 and NaHCO3 in 1-methyl-2-pyrrolidone at 140 C. The reaction of 2-bromo-6-methoxynaphthalene (I) with Mg in THF gives the expected Grignard reagent (VII), which is then condensed with 3-buten-2-one (II) by means of ZnCl2-amine complex in the same solvent.

参考文献中间体

合成目标

【1】 Aslam, M.; et al.; Convenient synthesis of nabumetone. Synthesis 1989, 869.
【2】 Wang, S.-M.; Chen, Z.-X.; Novel synthesis of nabumetone. Chin J Pharm 1989, 20, 4, 146.
【3】 Davenport, K.G.; Aslam, M. (Celanese AG); Method of preparation of nabumetone. EP 0376516 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	44399	2-bromo-6-methoxynaphthalene; 6-bromo-2-naphthyl methyl ether	5111-65-9	C₁₁H₉BrO	详情	详情
(II)	30324	3-buten-2-one; methyl vinyl ketone	78-94-4	C₄H₆O	详情	详情
(VI)	46055	3-buten-2-ol		C₄H₈O	详情	详情
(VII)	46056	bromo(6-methoxy-2-naphthyl)magnesium		C₁₁H₉BrMgO	详情	详情

Extended Information