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【结 构 式】 
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【分子编号】51337 【品名】N-[3-(aminosulfonyl)-5-chloro-2-thienyl]acetamide 【CA登记号】 |
【 分 子 式 】C6H7ClN2O3S2 【 分 子 量 】254.71796 【元素组成】C 28.29% H 2.77% Cl 13.92% N 11% O 18.84% S 25.18% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The thiocarbamoylation of the thiophenesulfonamide (I) with isopropyl isothiocyanate in the presence of potassium tert-butoxide furnished the sulfonyl thiourea (II). This was cyclized to the thienothiadiazine derivative (III) upon treatment with phosgene and triethylamine in cold THF. The acetyl group of (III) was finally removed by hydrolysis with NaOH.
| 【1】 Tagmose, T.M.; Hansen, H.C.; Nielsen, F.E.; Mogensen, J.P.; Hansen, J.B. (Novo Nordisk A/S); Fused 1,2,4-thiadiazine derivs., their preparation and use. EP 1000066; JP 2001510195; WO 9903861 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 51337 | N-[3-(aminosulfonyl)-5-chloro-2-thienyl]acetamide | C6H7ClN2O3S2 | 详情 | 详情 | |
| (II) | 51338 | N-[5-chloro-3-([[(isopropylamino)carbothioyl]amino]sulfonyl)-2-thienyl]acetamide | C10H14ClN3O3S3 | 详情 | 详情 | |
| (III) | 51339 | 4-acetyl-6-chloro-3-(isopropylamino)-2H-thieno[2,3-e][1,2,4]thiadiazine-1,1(4H)-dione | C10H12ClN3O3S2 | 详情 | 详情 |
Extended Information