4-pyridinylboronic acid -Drug Synthesis Database

【结构式】

【分子编号】44707

【品名】4-pyridinylboronic acid

【CA登记号】1692-15-5

【分子式】C₅H₆BNO₂

【分子量】122.91918

【元素组成】C 48.86% H 4.92% B 8.8% N 11.4% O 26.03%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Suzuki coupling of 4-bromonaphth-1-ylamine (I) with 4-pyridylboronic acid (II) furnished 4-(pyridyl)-1-naphthylamine (III), which was further converted into isocyanate (IV) by treatment with triphosgene.

参考文献中间体

合成目标

【1】 Evans, M.; Gaster, L.M.; Gordon, l.; et al.; Mixed 5-HT1A/1B/1D receptor antagonists as novel antidepressants. 16th Int Symp Med Chem (Sept 18 2000, Bologna) 2000, Abst PB-77.
【2】 Gaster, L.M.; Rami, H.K.; Wyman, P.A. (SmithKline Beecham plc); Indole derivs. having combined 5HT1A, 5HT1B and 5HT1D receptor antagonist activity. EP 0975593; WO 9850358 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	44706	4-bromo-1-naphthalenamine; 4-bromo-1-naphthylamine		C₁₀H₈BrN	详情	详情
(II)	44707	4-pyridinylboronic acid	1692-15-5	C₅H₆BNO₂	详情	详情
(III)	44708	4-(4-pyridinyl)-1-naphthalenamine; 4-(4-pyridinyl)-1-naphthylamine		C₁₅H₁₂N₂	详情	详情
(IV)	44709	4-(4-pyridinyl)-1-naphthyl isocyanate; 4-(4-isocyanato-1-naphthyl)pyridine		C₁₆H₁₀N₂O	详情	详情

Extended Information