【结 构 式】 |
【分子编号】43939 【品名】tert-butyl bis(2-chloroethyl)carbamate 【CA登记号】 |
【 分 子 式 】C9H17Cl2NO2 【 分 子 量 】242.14492 【元素组成】C 44.64% H 7.08% Cl 29.28% N 5.78% O 13.21% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)The intermediate piperidine (IV) was prepared by bis-alkylation of o-methylphenylacetonitrile (I) with N-Boc-bis(2-chloroethyl)amine (II), followed by deprotection of the resulting N-Boc-piperidine (III) with HCl in EtOAc.
【1】 Newton, R.C.; Freidinger, R.M.; Price, R.A.; Chang, R.S.L.; Patane, M.A.; DiPardo, R.M.; Di Salvo, J.; Broten, T.P.; Ransom, R.W.; Bock, M.G.; Cyclic imides as potent and selective alpha-1A adrenergic receptor antagonists. Bioorg Med Chem Lett 2001, 11, 14, 1959. |
【2】 Bell, M.G.; DiPardo, R.M.; Crowell, T.A.; et al.; Cyclic imides as potent and selective alpha-1A adrenergic receptor antagonists. 220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000, Abst MEDI 298. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 43938 | 2-(2-methylphenyl)acetonitrile | C9H9N | 详情 | 详情 | |
(II) | 43939 | tert-butyl bis(2-chloroethyl)carbamate | C9H17Cl2NO2 | 详情 | 详情 | |
(III) | 43940 | tert-butyl 4-cyano-4-(2-methylphenyl)-1-piperidinecarboxylate | C18H24N2O2 | 详情 | 详情 | |
(IV) | 43941 | 4-(2-methylphenyl)-4-piperidinecarbonitrile | C13H16N2 | 详情 | 详情 |
Extended Information