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【结 构 式】

【分子编号】43939

【品名】tert-butyl bis(2-chloroethyl)carbamate

【CA登记号】

【 分 子 式 】C9H17Cl2NO2

【 分 子 量 】242.14492

【元素组成】C 44.64% H 7.08% Cl 29.28% N 5.78% O 13.21%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

The intermediate piperidine (IV) was prepared by bis-alkylation of o-methylphenylacetonitrile (I) with N-Boc-bis(2-chloroethyl)amine (II), followed by deprotection of the resulting N-Boc-piperidine (III) with HCl in EtOAc.

1 Newton, R.C.; Freidinger, R.M.; Price, R.A.; Chang, R.S.L.; Patane, M.A.; DiPardo, R.M.; Di Salvo, J.; Broten, T.P.; Ransom, R.W.; Bock, M.G.; Cyclic imides as potent and selective alpha-1A adrenergic receptor antagonists. Bioorg Med Chem Lett 2001, 11, 14, 1959.
2 Bell, M.G.; DiPardo, R.M.; Crowell, T.A.; et al.; Cyclic imides as potent and selective alpha-1A adrenergic receptor antagonists. 220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000, Abst MEDI 298.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 43938 2-(2-methylphenyl)acetonitrile C9H9N 详情 详情
(II) 43939 tert-butyl bis(2-chloroethyl)carbamate C9H17Cl2NO2 详情 详情
(III) 43940 tert-butyl 4-cyano-4-(2-methylphenyl)-1-piperidinecarboxylate C18H24N2O2 详情 详情
(IV) 43941 4-(2-methylphenyl)-4-piperidinecarbonitrile C13H16N2 详情 详情
Extended Information