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【结 构 式】 
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【分子编号】43767 【品名】tribenzyl (3S,6S,9S,12S,15S,18S,21S,24S)-24-([(2S)-2-amino-3-[4-(benzyloxy)phenyl]propanoyl]amino)-18-(2-amino-2-oxoethyl)-12,15-bis[4-(benzyloxy)benzyl]-9-[(1R)-1-(benzyloxy)ethyl]-6-[(benzyloxy)methyl]-21-[(1S)-1-methylpropyl]-5,8,11,14,17,20,23-h 【CA登记号】 |
【 分 子 式 】C109H118N10O20 【 分 子 量 】1888.19132 【元素组成】C 69.34% H 6.3% N 7.42% O 16.95% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Cleavage of the Boc group from the protected peptide (I) by means of HCl in dioxan gave (II). To this was coupled the carboxylic acid (III) using EDC and HOBt to afford the corresponding amide (IV).
| 【1】 Konishi, K.; et al.; Synthesis of peptides mimicking chemokine receptor CCR5 and their inhibitory effects against HIV-1 infection. Chem Pharm Bull 2000, 48, 2, 308. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 43766 | tribenzyl (3S,6S,9S,12S,15S,18S,21S,24S)-18-(2-amino-2-oxoethyl)-12,15-bis[4-(benzyloxy)benzyl]-9-[(1R)-1-(benzyloxy)ethyl]-6-[(benzyloxy)methyl]-24-([(2S)-3-[4-(benzyloxy)phenyl]-2-[(tert-butoxycarbonyl)amino]propanoyl]amino)-21-[(1S)-1-methylpropy | C114H126N10O22 | 详情 | 详情 | |
| (II) | 43767 | tribenzyl (3S,6S,9S,12S,15S,18S,21S,24S)-24-([(2S)-2-amino-3-[4-(benzyloxy)phenyl]propanoyl]amino)-18-(2-amino-2-oxoethyl)-12,15-bis[4-(benzyloxy)benzyl]-9-[(1R)-1-(benzyloxy)ethyl]-6-[(benzyloxy)methyl]-21-[(1S)-1-methylpropyl]-5,8,11,14,17,20,23-h | C109H118N10O20 | 详情 | 详情 | |
| (III) | 19117 | 2-(2-[[(2R)-2-([[(2S)-1-(2-methoxy-2-oxoacetyl)pyrrolidinyl]carbonyl]amino)-3-phenylpropanoyl]amino]phenoxy)acetic acid | C25H27N3O8 | 详情 | 详情 | |
| (IV) | 43768 | tribenzyl (3S,6S,9S,12S,15S,18S,21S,24S)-18-(2-amino-2-oxoethyl)-12,15-bis[4-(benzyloxy)benzyl]-9-[(1R)-1-(benzyloxy)ethyl]-6-[(benzyloxy)methyl]-24-[((2S)-3-[4-(benzyloxy)phenyl]-2-[[2-(2-[[(2R)-2-([[(2S)-1-(2-methoxy-2-oxoacetyl)pyrrolidinyl]carbo | C134H142N12O28 | 详情 | 详情 |
Extended Information