2-(4-methyl-1-piperazinyl)acetic acid -Drug Synthesis Database

【结构式】

【分子编号】42595

【品名】2-(4-methyl-1-piperazinyl)acetic acid

【CA登记号】

【分子式】C₇H₁₄N₂O₂

【分子量】158.20044

【元素组成】C 53.15% H 8.92% N 17.71% O 20.23%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The hydroxyethyl ester of naproxen (II) was synthesized by treatment of the sodium salt of naproxen (I) with 2-bromoethanol. Condensation of (II) with (4-methyl-1-piperazinyl)acetic acid (III) in the presence of dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine yielded the title compound.

参考文献中间体

合成目标

【1】 Rautio, J.; et al.; Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery. J Med Chem 2000, 43, 8, 1489.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	42596	2-(6-methoxy-2-naphthyl)propionic acid	23981-80-8	C₁₄H₁₄O₃	详情	详情
(II)	42594	2-hydroxyethyl 2-(6-methoxy-2-naphthyl)propanoate		C₁₆H₁₈O₄	详情	详情
(III)	42595	2-(4-methyl-1-piperazinyl)acetic acid		C₇H₁₄N₂O₂	详情	详情

Extended Information