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【结 构 式】 
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【分子编号】42483 【品名】1-allyl 4-[(2S,3R,6S,8R,9S)-8-((2E,4E,6R,7S,8E)-10-(allyloxy)-6-[[tert-butyl(dimethyl)silyl]oxy]-3,7-dimethyl-10-oxo-2,4,8-decatrienyl)-2-[(1E,3E)-5-(allyloxy)-3-methyl-5-oxo-1,3-pentadienyl]-3-butyl-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] succinate 【CA登记号】 |
【 分 子 式 】C51H78O11Si 【 分 子 量 】895.25922 【元素组成】C 68.42% H 8.78% O 19.66% Si 3.14% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXXVIII)The condensation of (XXXVI) with phosphorane (XXXVII) in hot toluene gives the fully protected target compound (XXXVIII), which is deallylated by means of Pd(PPh3)4 and PPh3 in pyrrolidine/dichloromethane, yielding intermediate (XXXIX). Finally, this compound is desilylated by means of TBAF in DMF.
| 【1】 Shimizu, T.; et al.; Total synthesis of reveromycin A. Org Lett 2000, 2, 14, 2153. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XXXVI) | 42481 | 1-allyl 4-[(2S,3R,6S,8R,9S)-2-[(1E,3E)-5-(allyloxy)-3-methyl-5-oxo-1,3-pentadienyl]-3-butyl-8-((2E,4E,6S,7R)-6-[[tert-butyl(dimethyl)silyl]oxy]-3,7-dimethyl-8-oxo-2,4-octadienyl)-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] succinate | C46H72O10Si | 详情 | 详情 | |
| (XXXVII) | 42482 | allyl 2-(triphenylphosphoranylidene)acetate | C23H21O2P | 详情 | 详情 | |
| (XXXVIII) | 42483 | 1-allyl 4-[(2S,3R,6S,8R,9S)-8-((2E,4E,6R,7S,8E)-10-(allyloxy)-6-[[tert-butyl(dimethyl)silyl]oxy]-3,7-dimethyl-10-oxo-2,4,8-decatrienyl)-2-[(1E,3E)-5-(allyloxy)-3-methyl-5-oxo-1,3-pentadienyl]-3-butyl-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] succinate | C51H78O11Si | 详情 | 详情 | |
| (XXXIX) | 42484 | (2E,4S,5R,6E,8E)-10-[(2R,3S,6S,8S,9R)-9-butyl-8-[(1E,3E)-4-carboxy-3-methyl-1,3-butadienyl]-9-[(3-carboxypropanoyl)oxy]-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]-5-[[tert-butyl(dimethyl)silyl]oxy]-4,8-dimethyl-2,6,8-decatrienoic acid | C42H66O11Si | 详情 | 详情 |
Extended Information