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【结 构 式】 
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【分子编号】41950 【品名】3-[3,4-dihydro-1(2H)-quinolinylsulfonyl]phenylamine; 3-[3,4-dihydro-1(2H)-quinolinylsulfonyl]aniline 【CA登记号】 |
【 分 子 式 】C15H16N2O2S 【 分 子 量 】288.37032 【元素组成】C 62.48% H 5.59% N 9.71% O 11.1% S 11.12% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Condensation of 3-nitrobenzenesulfonyl chloride (I) with tetrahydroquinoline (II) in the presence of pyridine gave sulfonamide (III). Reduction of the nitro group of (III) with stannous chloride produced the aniline derivative (IV). The title compound was then obtained by reductive alkylation of amine (IV) with 4-formylimidazole (V) using sodium triacetoxyborohydride as the reducing reagent.
| 【1】 Hunt, J.T.; Manne, V.; Ding, C.Z.; Ricca, C.; 3-Imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a novel series of farnesyltransferase inhibitors. Bioorg Med Chem Lett 2000, 10, 3, 273. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 41948 | 3-nitrobenzenesulfonyl chloride | 121-51-7 | C6H4ClNO4S | 详情 | 详情 |
| (II) | 23859 | 1,2,3,4-tetrahydroquinoline | 635-46-1 | C9H11N | 详情 | 详情 |
| (III) | 41949 | 1-[(3-nitrophenyl)sulfonyl]-1,2,3,4-tetrahydroquinoline | C15H14N2O4S | 详情 | 详情 | |
| (IV) | 41950 | 3-[3,4-dihydro-1(2H)-quinolinylsulfonyl]phenylamine; 3-[3,4-dihydro-1(2H)-quinolinylsulfonyl]aniline | C15H16N2O2S | 详情 | 详情 | |
| (V) | 41951 | 1H-imidazole-5-carbaldehyde | 3034-50-2 | C4H4N2O | 详情 | 详情 |
Extended Information