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【结 构 式】 
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【分子编号】40918 【品名】methyl 2,5-diamino-2-(difluoromethyl)pentanoate 【CA登记号】 |
【 分 子 式 】C7H14F2N2O2 【 分 子 量 】196.1972464 【元素组成】C 42.85% H 7.19% F 19.37% N 14.28% O 16.31% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The optical resolution of 2,5-diamino-2-(difluoromethyl)pentanoic acid is performed as follows: The cyclization of its corresponding methyl ester (I) by means of sodium methoxide in methanol gives the racemic piperidone (II), which is submitted to optical resolution with (-)-binaphthylphosphoric acid yielding after crystallization and acidification with HCl the (+) and (-) piperidones (III) and (IV). Finally, both compounds are treated with refluxing 6N HCl to afford the target enantiomers.
| 【1】 Jung, M.; Bey, P. (Aventis Pharma SA); 2-(Difluoromethyl)-2,5-diaminopentanoic acid. US 4413141 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 40918 | methyl 2,5-diamino-2-(difluoromethyl)pentanoate | C7H14F2N2O2 | 详情 | 详情 | |
| (II) | 40919 | 3-amino-3-(difluoromethyl)-2-piperidinone | C6H10F2N2O | 详情 | 详情 | |
| (III) | 40920 | (3R)-3-amino-3-(difluoromethyl)-2-piperidinone | C6H10F2N2O | 详情 | 详情 | |
| (IV) | 40921 | (3S)-3-amino-3-(difluoromethyl)-2-piperidinone | C6H10F2N2O | 详情 | 详情 |
Extended Information