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【结 构 式】 
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【分子编号】40620 【品名】(2R,3R,4R,5R,6R)-3-amino-2-[[(2R,3S,4R,5R,6R)-5-amino-6-(benzyloxy)-3,4-dihydroxytetrahydro-2H-pyran-2-yl]methoxy]-5-[(diphenoxyphosphoryl)oxy]-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl (3R)-3-(tetradecanoyloxy)tetradecanoate 【CA登记号】 |
【 分 子 式 】C59H91N2O15P 【 分 子 量 】1099.349782 【元素组成】C 64.46% H 8.34% N 2.55% O 21.83% P 2.82% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVI)In a related procedure for the synthesis of the protected precursor (XIV), the known bis(trichloroethoxycarbonyl) derivative (XV) was coupled with glycosyl chloride (XII) to give the corresponding disaccharide which was deprotected to (XVI) upon treatment with Zn/AcOH. Bis N-acylation of (XV) with acid (II) in the presence of EEDQ then provided the target intermediate (XIV).
| 【1】 Sowell, C.G.; Johnson, D.A.; Keegan, D.S.; et al.; 3-O-Desacyl monophosphoryl lipid A derivatives: Synthesis and immunostimulant activities. J Med Chem 1999, 42, 22, 4640. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 40612 | (3R)-3-(tetradecanoyloxy)tetradecanoic acid | C28H54O4 | 详情 | 详情 | |
| (XII) | 40616 | (2R,3R,4R,5S,6R)-2-chloro-5-[(diphenoxyphosphoryl)oxy]-6-([[(2,2,2-trichloro-1,1-dimethylethoxy)carbonyl]oxy]methyl)-3-[[(2,2,2-trichloroethoxy)carbonyl]amino]tetrahydro-2H-pyran-4-yl (3R)-3-(tetradecanoyloxy)tetradecanoate | C54H79Cl7NO14P | 详情 | 详情 | |
| (XIV) | 40618 | C115H195N2O21P | 详情 | 详情 | ||
| (XV) | 40619 | (2R,3R,4R,5R,6R)-2-(benzyloxy)-5-hydroxy-6-(hydroxymethyl)-3-[[(2,2,2-trichloroethoxy)carbonyl]amino]tetrahydro-2H-pyran-4-yl 2,2,2-trichloroethyl carbonate | C19H21Cl6NO9 | 详情 | 详情 | |
| (XVI) | 40620 | (2R,3R,4R,5R,6R)-3-amino-2-[[(2R,3S,4R,5R,6R)-5-amino-6-(benzyloxy)-3,4-dihydroxytetrahydro-2H-pyran-2-yl]methoxy]-5-[(diphenoxyphosphoryl)oxy]-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl (3R)-3-(tetradecanoyloxy)tetradecanoate | C59H91N2O15P | 详情 | 详情 |
Extended Information