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【结 构 式】

【分子编号】40440

【品名】5,8-dihydro-1-naphthalenol

【CA登记号】27673-48-9

【 分 子 式 】C10H10O

【 分 子 量 】146.1888

【元素组成】C 82.16% H 6.89% O 10.94%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The esterification of 5,8-dihydro-1-naphthol (I) with acetic anhydride gives the corresponding acetate (II), which is oxidized with silver acetate and I2 in acetic acid to yield 2,3-cis-1,2,3,4-tetrahydro-2,3,5-naphthalenetriol (III). The treatment of this product with sodium methylate and epichlorhydrin (A) in methanol gives 2,3-cis-1,2,3,4-tetrahydro-5-(2,3-epoxypropoxy)-2,3-naphthalenediol (IV), which is finally treated with tertbutylamine (B) in chloroform-methanol.

1 Hanck, F.P.; et al.; Tetrahydronaphthyloxyaminopropanols and related compounds. CA 979926; DE 2258995; GB 1358722 .
2 Weetman, D.F.; Castaner, J.; Nadolol. Drugs Fut 1976, 1, 9, 434.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(A) 10146 Epichlorohydrin; 2-(Chloromethyl)oxirane 106-89-8 C3H5ClO 详情 详情
(B) 17895 2-Amino-2-methylpropane; tert-butylamine; 2-methyl-2-propanamine 75-64-9 C4H11N 详情 详情
(I) 40440 5,8-dihydro-1-naphthalenol 27673-48-9 C10H10O 详情 详情
(II) 40441 1-naphthyl acetate 830-81-9 C12H10O2 详情 详情
(III) 40442 (6R,7S)-5,6,7,8-tetrahydro-1,6,7-naphthalenetriol C10H12O3 详情 详情
(IV) 40443 (2R,3S)-5-(2-oxiranylmethoxy)-1,2,3,4-tetrahydro-2,3-naphthalenediol C13H16O4 详情 详情
Extended Information