5-methoxy-3,4-dihydro-2(1H)-quinolinone -Drug Synthesis Database

【结构式】

【分子编号】38679

【品名】5-methoxy-3,4-dihydro-2(1H)-quinolinone

【CA登记号】

【分子式】C₁₀H₁₁NO₂

【分子量】177.20288

【元素组成】C 67.78% H 6.26% N 7.9% O 18.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The condensation of 5-methoxy-1,2,3,4-tetrahydroquinolin-2-one (I) with 1,3-dichloropropane (II) by means of NaH in DMF gives 1-(3-chloropropyl)-5-methoxy-1,2,3,4-tetrahydroquinolin-2-one (II), which is finally condensed with 1-(3-chlorophenyl)piperazine (IV) by means of NaI and K2CO3 in acetonitrile.

参考文献中间体

合成目标

【1】 Oshiro, Y.; et al.; 3,4-Dihydro-2(1H)-quinolinone as a novel antidepressant drug: Synthesis and pharmacology of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-3,4-dihydro-5-methoxy-2(1H)-quinolinone and its derivatives. J Med Chem 2000, 43, 2, 177.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	38679	5-methoxy-3,4-dihydro-2(1H)-quinolinone		C₁₀H₁₁NO₂	详情	详情
(II)	38680	1,3-dichloropropane	142-28-9	C₃H₆Cl₂	详情	详情
(III)	38681	1-(3-chloropropyl)-5-methoxy-3,4-dihydro-2(1H)-quinolinone		C₁₃H₁₆ClNO₂	详情	详情
(IV)	22114	1-(3-chlorophenyl)piperazine	6640-24-0	C₁₀H₁₃ClN₂	详情	详情

Extended Information