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【结 构 式】 
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【分子编号】38675 【品名】(2S)-2-amino-2-phenylethyl hydrogen sulfate 【CA登记号】 |
【 分 子 式 】C8H11NO4S 【 分 子 量 】217.24568 【元素组成】C 44.23% H 5.1% N 6.45% O 29.46% S 14.76% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)The esterification of 2(S)-amino-2-phenylethanol (VII) with hot sulfuric acid gives the expected O-sulfate (VIII), which by treatment with hot aqueous NaOH yields the aziridine (IX). The condensation of (IX) with imidazole (VI) by heating at 120 C affords 2(R)-(1-imidazolyl)-2-phenylethan-1-amine (X). Finally, this compound is condensed with 4'-chlorobiphenyl-4-thiocarboxylic acid 2-pyridylthioester in DMF.
| 【1】 Schuster, I.; Egger, H. (Novartis AG; Novartis Deutschland GmbH); Acylated aminoalkanimidazoles and -triazoles. CA 2149459; EP 0683156; JP 1996053422; US 5622982 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |
| (VII) | 10973 | (2S)-2-Amino-2-phenyl-1-ethanol; (S)-2-Hydroxy-1-phenylethylamine; (S)-(+)-2-Phenylglycinol; (S)-2-Amino-2-phenyl-1-ethanol | 20989-17-7 | C8H11NO | 详情 | 详情 |
| (VIII) | 38675 | (2S)-2-amino-2-phenylethyl hydrogen sulfate | C8H11NO4S | 详情 | 详情 | |
| (IX) | 38676 | (2S)-2-phenylaziridine | C8H9N | 详情 | 详情 | |
| (X) | 38677 | (2R)-2-(1H-imidazol-1-yl)-2-phenyl-1-ethanamine; (2R)-2-(1H-imidazol-1-yl)-2-phenylethylamine | C11H13N3 | 详情 | 详情 | |
| (XI) | 38678 | S-(2-pyridinyl) 4'-chloro[1,1'-biphenyl]-4-carbothioate | C18H12ClNOS | 详情 | 详情 |
Extended Information