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【结 构 式】

【分子编号】38580

【品名】2-[[[(1S)-2-methyl-1-(propionyloxy)propyl]oxy](4-phenylbutyl)phosphoryl]acetic acid

【CA登记号】

【 分 子 式 】C19H29O6P

【 分 子 量 】384.409422

【元素组成】C 59.37% H 7.6% O 24.97% P 8.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XXVIII)

The reaction of 4-phenyl-1-butene (XX) with hypophosphorous acid gives 4-phenylbutylphosphinic acid (XXI), which is condensed with chloroacetic acid (XXII) yielding 2-[hydroxy(4-phenylbutyl)phosphoryl]acetic acid (XXIII). The esterifica-tion of (XXII) with benzyl alcohol affords the benzyl acetate (XXIV), which is esterified at the OH group of the phosphinic acid with 2-methyl-1-(propionyloxy)propyl chloride (XXV) giving the completely esterified derivative (XXVI). The debenzylation of (XXVI) with H2 over Pd/C yields the acetic acid derivative (XXVII), which is submitted to optical resolution affording the desired (S)-isomer (XXVIII). Finally, this compound is condensed with the desired intermediate trans-4-cyclohexyl-L-proline (XI) by means of CDI and NaOH.

1 Anderson, N.G.; et al.; Generation and fate of regioisomeric side-chain impurities in the preparation of fosinopril sodium. Org Process Res Dev 1997, 1, 4, 315.
2 Anderson, N.G.; et al.; Process development for the preparation of a monopril intermediate by a trimethylsilyl-modified arbuzov reaction. Org Process Res Dev 1997, 1, 3, 211.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XI) 38567 (2S,4S)-4-cyclohexyl-2-pyrrolidinecarboxylic acid C11H19NO2 详情 详情
(XX) 20933 1-(3-butenyl)benzene 768-56-9 C10H12 详情 详情
(XXI) 20932 4-phenylbutylphosphinic acid C10H15O2P 详情 详情
(XXII) 11847 2-Chloroacetic acid; Chloroacetic Acid 79-11-8 C2H3ClO2 详情 详情
(XXIII) 38575 2-[hydroxy(4-phenylbutyl)phosphoryl]acetic acid C12H17O4P 详情 详情
(XXIV) 38576 2-(benzyloxy)-2-oxoethyl(4-phenylbutyl)phosphinic acid C19H23O4P 详情 详情
(XXV) 38577 1-chloro-2-methylpropyl propionate C7H13ClO2 详情 详情
(XXVI) 38578 1-[[[2-(benzyloxy)-2-oxoethyl](4-phenylbutyl)phosphoryl]oxy]-2-methylpropyl propionate C26H35O6P 详情 详情
(XXVII) 38579 2-[[2-methyl-1-(propionyloxy)propoxy](4-phenylbutyl)phosphoryl]acetic acid C19H29O6P 详情 详情
(XXVIII) 38580 2-[[[(1S)-2-methyl-1-(propionyloxy)propyl]oxy](4-phenylbutyl)phosphoryl]acetic acid C19H29O6P 详情 详情
Extended Information