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【结 构 式】 
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【分子编号】35793 【品名】4-(2-amino-9H-purin-9-yl)-2-(hydroxymethyl)butyl acetate 【CA登记号】 |
【 分 子 式 】C12H17N5O3 【 分 子 量 】279.29888 【元素组成】C 51.6% H 6.13% N 25.07% O 17.19% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)6-Deoxypenciclovir (I) was reacted with trimethyl orthoacetate in the presence of p-toluenesulfonic acid to give the cyclic orthoacetate intermediate (II) which, after aqueous quenching, afforded monoacetate ester (III). Subsequent treatment of (III) with isopropyl p-nitrophenyl carbonate (IV) using a catalytic amount of dimethylaminopyridine provided the target carbonate ester.
| 【1】 Kim, D.-K.; et al.; Synthesis and evaluation of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-amino-9-(3-alkoxycarbonyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines as potential prodrugs of penciclovir. Bioorg Med Chem 1999, 7, 8, 1715. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11643 | 2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol | C10H15N5O2 | 详情 | 详情 | |
| (II) | 35792 | 9-[2-(2-methoxy-2-methyl-1,3-dioxan-5-yl)ethyl]-9H-purin-2-ylamine; 9-[2-(2-methoxy-2-methyl-1,3-dioxan-5-yl)ethyl]-9H-purin-2-amine | C13H19N5O3 | 详情 | 详情 | |
| (III) | 35793 | 4-(2-amino-9H-purin-9-yl)-2-(hydroxymethyl)butyl acetate | C12H17N5O3 | 详情 | 详情 | |
| (IV) | 35794 | isopropyl 4-nitrophenyl carbonate | C10H11NO5 | 详情 | 详情 |
Extended Information