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【结 构 式】

【分子编号】33569

【品名】2-chloro-1-(3-chlorophenyl)-1-propanone

【CA登记号】

【 分 子 式 】C9H8Cl2O

【 分 子 量 】203.06732

【元素组成】C 53.23% H 3.97% Cl 34.92% O 7.88%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

By reaction of alpha,m-(dichloropropiophenone (I) with tert-butylamine (B) in refluxing acetonitrile or by reaction of alpha-bromo-m-chloropropiophenone (VI) with tert-butylamine (B) in acetonitrile at room temperature. The starting product (I) can be obtained in two different ways: 1) The Grignard condensation of m-chlorobenzonitrile (II) with ethyl magnesium bromide (A) in refluxing ether gives m-chloropropiophenone (III), which is then treated with SO2Cl2 in tetrachloroethane. 2) The reaction of propiophenone (IV) with SO2Cl2 in tetrachloroethane gives alpha-chloropropiophenone (V), which is then chlorinated in the ring by means of SO2Cl2 and AlCl3 in tetrachloroethane. The starting product (VI) is obtained by bromination of m-chloropropiophenone (III) with Br2 in methylene chloride

1 Mehta, N.B.; Yeowell, D.A.; Intermediates for biologically active ketones. CA 977778 .
2 Mehta, N.B.; Yeowell, D.A.; Amino-propiophenones et medicaments contenant ces substances. DE 2059618; DE 2064934; FR 2081326; US 3819706 .
3 Hopkins, S.J.; Castaner, J.; Bupropion. Drugs Fut 1978, 3, 10, 723.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(B) 17895 2-Amino-2-methylpropane; tert-butylamine; 2-methyl-2-propanamine 75-64-9 C4H11N 详情 详情
(A) 24239 bromo(ethyl)magnesium;ethylmagnesium bromide 925-90-6 C2H5BrMg 详情 详情
(I) 33569 2-chloro-1-(3-chlorophenyl)-1-propanone C9H8Cl2O 详情 详情
(II) 33570 3-chlorobenzonitrile 766-84-7 C7H4ClN 详情 详情
(III) 33571 3'-chloropropiophenone; 1-(3-chlorophenyl)-1-propanone 34841-35-5 C9H9ClO 详情 详情
(IV) 33531 propiophenone 93-55-0 C9H10O 详情 详情
(V) 33572 2-chloro-1-phenyl-1-propanone C9H9ClO 详情 详情
(VI) 33573 2-bromo-1-(3-chlorophenyl)-1-propanone C9H8BrClO 详情 详情
Extended Information