1-(4-methyl-3-pentenyl)-4-piperidinone -Drug Synthesis Database

【结构式】

【分子编号】31464

【品名】1-(4-methyl-3-pentenyl)-4-piperidinone

【CA登记号】

【分子式】C₁₁H₁₉NO

【分子量】181.278

【元素组成】C 72.88% H 10.56% N 7.73% O 8.83%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The alkylation of 4-piperidone monohydrate hydrochloride (I) with 5-bromo-2-methyl-2-pentene (II) in the presence of KI and K2CO3 afforded the tertiary amine (III). Subsequent reductive amination using ammonium acetate and sodium cyanoborohydride provided aminopiperidine (IV).

参考文献中间体

合成目标

【1】 Mase, T.; Mitsuya, M.; Tsuchiya, Y.; et al.; J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors. Bioorg Med Chem 1999, 7, 11, 2555.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	27115	4-piperidinone	40064-34-4	C₅H₉NO	详情	详情
(II)	31462	5-bromo-2-methyl-2-pentene		C₆H₁₁Br	详情	详情
(III)	31464	1-(4-methyl-3-pentenyl)-4-piperidinone		C₁₁H₁₉NO	详情	详情
(IV)	31463	1-(4-methyl-3-pentenyl)-4-piperidinamine; 1-(4-methyl-3-pentenyl)-4-piperidinylamine		C₁₁H₂₂N₂	详情	详情

Extended Information