(2S)-2-ethylpiperazine -Drug Synthesis Database

【结构式】

【分子编号】31461

【品名】(2S)-2-ethylpiperazine

【CA登记号】

【分子式】C₆H₁₄N₂

【分子量】114.19064

【元素组成】C 63.11% H 12.36% N 24.53%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

Reaction of 2-chloro-5-acetylpyridine (I) with refluxing dimethylformamide diethylacetal (II) afforded the enaminoketone (III). Subsequent condensation of (III) with 3,4,5-trimethoxyphenylguanidinium nitrate (IV) in the presence of NaOH gave rise to the pyridinyl pyrimidine (V). Finally, displacement of the halogen atom of (V) with (S)-2-ethylpiperazine (VI) yielded the title compound.

参考文献中间体

合成目标

【1】 Davis, P.; Hutchings, M.; Moffat, D.; et al.; 4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: Potent and selective inhibitors of ZAP 70. Bioorg Med Chem Lett 1999, 9, 23, 3351.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	26555	1-(6-chloro-3-pyridinyl)-1-ethanone		C₇H₆ClNO	详情	详情
(II)	31457	N-(diethoxymethyl)-N,N-dimethylamine; diethoxy-N,N-dimethylmethanamine	1188-33-6	C₇H₁₇NO₂	详情	详情
(III)	31458	(E)-1-(6-chloro-3-pyridinyl)-3-(dimethylamino)-2-propen-1-one		C₁₀H₁₁ClN₂O	详情	详情
(IV)	31459	N-(3,4,5-Trimethoxyphenyl)guanidinium nitrate		C₁₀H₁₆N₄O₆	详情	详情
(V)	31460	N-[4-(6-chloro-3-pyridinyl)-2-pyrimidinyl]-N-(3,4,5-trimethoxyphenyl)amine; 4-(6-chloro-3-pyridinyl)-N-(3,4,5-trimethoxyphenyl)-2-pyrimidinamine		C₁₈H₁₇ClN₄O₃	详情	详情
(VI)	31461	(2S)-2-ethylpiperazine		C₆H₁₄N₂	详情	详情

Extended Information