4-amino-2-chloro-5-(1H-1,2,3,4-tetraazol-5-yl)benzenesulfonamide -Drug Synthesis Database

【结构式】

【分子编号】30733

【品名】4-amino-2-chloro-5-(1H-1,2,3,4-tetraazol-5-yl)benzenesulfonamide

【CA登记号】

【分子式】C₇H₇ClN₆O₂S

【分子量】274.69052

【元素组成】C 30.61% H 2.57% Cl 12.91% N 30.59% O 11.65% S 11.67%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

A new synthetic procedure for azosemide has been reported: The condensation of 2-formylthiophene (I) with 2-chloro-4-amino-5-(5-tetrazolyl)benzenesulfonamide (II) by means of polyphosphoric acid (PPA) in DMSO gives the corresponding Schiff base (III), which is reduced with KBH4 in the same solvent.

参考文献中间体

合成目标

【1】 Baetz, F.; Lauer, K. (Boehringer Ingelheim GmbH); Process for the production of 5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)phenyltetrazole. DE 3034664; JP 57081485 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	30732	2-thiophenecarbaldehyde; Thiophene-2-carboxaldehyde	98-03-3	C₅H₄OS	详情	详情
(II)	30733	4-amino-2-chloro-5-(1H-1,2,3,4-tetraazol-5-yl)benzenesulfonamide		C₇H₇ClN₆O₂S	详情	详情
(III)	30734	2-chloro-5-(1H-1,2,3,4-tetraazol-5-yl)-4-[[(E)-2-thienylmethylidene]amino]benzenesulfonamide		C₁₂H₉ClN₆O₂S₂	详情	详情

Extended Information