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【结 构 式】 
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【分子编号】30592 【品名】2-(chloroselanyl)benzoyl chloride 【CA登记号】 |
【 分 子 式 】C7H4Cl2OSe 【 分 子 量 】253.97356 【元素组成】C 33.1% H 1.59% Cl 27.92% O 6.3% Se 31.09% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The neutralized diazonium salt of anthranilic acid (I) is treated with sodium diselenide yielding diselenosalicylic acid (II), which is treated with thionyl chloride to give the selenenyl chloride (III). Treatment of (III) with aniline (IV) in the presence of a base affords PZ-51.
| 【1】 Renson, M.; Etschenberg, E.; Winkelmann, J. (A. Nattermann & Cie. GmbH); 2-Phenyl-1,2-benzisoselenazol-3(2H)-one containing pharmaceutical preparations and process for the treatment or rheumatic diseases. DE 3027073; EP 0044971; JP 8256427; US 4352799 . |
| 【2】 Graf, E.; Dereu, N.; Ebselen. Drugs Fut 1984, 9, 10, 741. |
Extended Information