9-oxo-9H-fluorene-4-carbonyl chloride -Drug Synthesis Database

【结构式】

【分子编号】29595

【品名】9-oxo-9H-fluorene-4-carbonyl chloride

【CA登记号】

【分子式】C₁₄H₇ClO₂

【分子量】242.66108

【元素组成】C 69.3% H 2.91% Cl 14.61% O 13.19%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Fluorenone-4-carboxaldehyde (II) was obtained by reduction of acid chloride (I). Subsequent Hantzsch synthesis using allyl acetoacetate (III) and ammonium hydroxide in boiling isopropyl alcohol provided the title dihydropyridine.

参考文献中间体

合成目标

【1】 Valenti, P.; Brudiesi, R.; Rampa, A.; Chiarini, A.; Fluorenone and benzophenone 1,4-dihydropyridine derivatives with cardiodepressant activity. Arzneim-Forsch Drug Res 1992, 42, 11, 1284.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29595	9-oxo-9H-fluorene-4-carbonyl chloride		C₁₄H₇ClO₂	详情	详情
(II)	29596	9-oxo-9H-fluorene-4-carbaldehyde		C₁₄H₈O₂	详情	详情
(III)	22675	allyl 3-oxobutanoate	1118-84-9	C₇H₁₀O₃	详情	详情

Extended Information