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【结 构 式】 
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【分子编号】29283 【品名】benzyl 2-([[(2R,3S)-2-[3-(3,3-diphenylpropyl)-2-oxo-1-imidazolidinyl]-3-(1H-indol-3-yl)butanoyl]amino]methyl)-1,3-dioxan-5-ylcarbamate 【CA登记号】 |
【 分 子 式 】C43H47N5O6 【 分 子 量 】729.87628 【元素组成】C 70.76% H 6.49% N 9.6% O 13.15% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XI)Coupling of (IX) with monoprotected diamine (X) by means of EDC and HOBt to furnish amide (XI). Finally, deprotecion of the amino group of (XI) afforded the title compound.
| 【1】 Marino, D.; Pan, Y.; Pasternak, A.; et al.; Potent, orally bioavailable somatostatin agonists: Good absorption achieved by urea backbone cyclization. Bioorg Med Chem Lett 1999, 9, 3, 491. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 29281 | (2R,3S)-2-[3-(3,3-diphenylpropyl)-2-oxo-1-imidazolidinyl]-3-(1H-indol-3-yl)butyric acid | C30H31N3O3 | 详情 | 详情 | |
| (X) | 29282 | benzyl 2-(aminomethyl)-1,3-dioxan-5-ylcarbamate | C13H18N2O4 | 详情 | 详情 | |
| (XI) | 29283 | benzyl 2-([[(2R,3S)-2-[3-(3,3-diphenylpropyl)-2-oxo-1-imidazolidinyl]-3-(1H-indol-3-yl)butanoyl]amino]methyl)-1,3-dioxan-5-ylcarbamate | C43H47N5O6 | 详情 | 详情 |
Extended Information