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【结 构 式】 
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【分子编号】27822 【品名】4-[(E)-3-amino-3-oxo-1-propenyl]phenyl acetate 【CA登记号】 |
【 分 子 式 】C11H11NO3 【 分 子 量 】205.21328 【元素组成】C 64.38% H 5.4% N 6.83% O 23.39% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)The acylation of (E)-3-(4-hydroxyphenyl)-2-propenamide (VI) with acetic anhydride gives the 4[(E)-3-amino-3-oxo-1-propenyl]phenyl acetate (VII), which by reaction first with BF3 ethearate and then with ammonia is converted into the amidine (IV). Finally, this compound is condensed with 2-furylcarbonyl chloride (V) in pyridine and treated with methanesulfonic acid to afford the target sulfonate.
| 【1】 Niwas, S.; Moore, R.; Kilpatrick, J.M.; Babu, Y.S.; Johnson, H.; Kellogg, D.; Development of novel inhibitors of complement and coagulation serine proteases. 216th ACS Natl Meet (Aug. 23-27, Boston) 1998, Abst MEDI 088. |
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