2-(4-chlorophenyl)-2,3,5,6-tetrahydro[1,2,4]triazolo[5,1-a]isoquinoline -Drug Synthesis Database

【结构式】

【分子编号】27358

【品名】2-(4-chlorophenyl)-2,3,5,6-tetrahydro[1,2,4]triazolo[5,1-a]isoquinoline

【CA登记号】

【分子式】C₁₆H₁₄ClN₃

【分子量】283.76008

【元素组成】C 67.72% H 4.97% Cl 12.49% N 14.81%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The cyclization of 2-amino-3,4-dihydro-1(2H)-isoquinolinone (I) with ethyl 4-chlorobenzimidate (II) by heating at 125 C under vacuum gives 2-(4-chloro-phenyl)-5,6-dihydro-s-triazolo[5,1-a]isoquinoline (III), which is dehydrogenated by means of N-bromoacetamide in refluxing CCl4.

参考文献中间体

合成目标

【1】 Consonni, P.; Lerner, L.; Omodei-Salé, A. (Lepetit SpA); 2-Substd. phenyl-5-triazols[5,1-a]isoquinoline cpds. US 4075341 .
【2】 de Angelis, L.; Castaner, J.; Lotrifen. Drugs Fut 1985, 10, 10, 817.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	27356	2-amino-3,4-dihydro-1(2H)-isoquinolinone	C₉H₁₀N₂O	详情	详情
(II)	27357	ethyl 4-chlorobenzenecarboximidoate	C₉H₁₀ClNO	详情	详情
(III)	27358	2-(4-chlorophenyl)-2,3,5,6-tetrahydro[1,2,4]triazolo[5,1-a]isoquinoline	C₁₆H₁₄ClN₃	详情	详情

Extended Information