methyl (E)-3-iodo-2-propenoate -Drug Synthesis Database

【结构式】

【分子编号】26749

【品名】methyl (E)-3-iodo-2-propenoate

【CA登记号】

【分子式】C₄H₅IO₂

【分子量】211.98697

【元素组成】C 22.66% H 2.38% I 59.86% O 15.09%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XVII)

Silylated propenoate (VII): The reaction of 3-iodopropenoic acid methyl ester (XVII) with phenyldimethylsilyllithium and CuCN in THF gives the corresponding silylated compound (XVIII), which is then treated with trifluoromethanesulfonic acid in dichloromethane to afford the target intermediate (VII).

参考文献中间体

合成目标

【1】 Brosius, A.D.; et al.; Total synthesis of (+)-aloperine. Use of a nitrogen-bound silicon tether in a intramolecular diels - Alder reaction. J Am Chem Soc 1999, 121, 4, 700.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(VII)	26750	methyl (E)-3-(dimethyl[[(trifluoromethyl)sulfonyl]oxy]silyl)-2-propenoate	C₇H₁₁F₃O₅SSi	详情	详情
(XVII)	26749	methyl (E)-3-iodo-2-propenoate	C₄H₅IO₂	详情	详情
(XVIII)	26740	methyl (E)-3-[dimethyl(phenyl)silyl]-2-propenoate	C₁₂H₁₆O₂Si	详情	详情

Extended Information