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【结 构 式】 
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【分子编号】26740 【品名】methyl (E)-3-[dimethyl(phenyl)silyl]-2-propenoate 【CA登记号】 |
【 分 子 式 】C12H16O2Si 【 分 子 量 】220.34334 【元素组成】C 65.41% H 7.32% O 14.52% Si 12.75% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVIII)Silylated propenoate (VII): The reaction of 3-iodopropenoic acid methyl ester (XVII) with phenyldimethylsilyllithium and CuCN in THF gives the corresponding silylated compound (XVIII), which is then treated with trifluoromethanesulfonic acid in dichloromethane to afford the target intermediate (VII).
| 【1】 Brosius, A.D.; et al.; Total synthesis of (+)-aloperine. Use of a nitrogen-bound silicon tether in a intramolecular diels - Alder reaction. J Am Chem Soc 1999, 121, 4, 700. |
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